|
T30937 |
Cimicoxib
|
UR-8880,UR8880,trade name: Cimalgex |
COX
|
|
Cimicoxib (UR8880) is a potent and selective inhibitor of COX-2 with anti-inflammatory and analgesic activity. |
|
T22360 |
MDR-652
|
|
TRP/TRPV Channel
|
|
MDR-652 is a highly specific and efficacious agonist of nonpungent transient receptor potential vanilloid 1 (TRPV1) with Ki value of 11.4 nM and 23.8 nM for hTRPV1 and rTRPV1 respectively and EC50s for hTRPV1 and rTRPV1 ... |
|
T22330 |
Fenamic acid
|
2-Anilinobenzoic acid,Diphenylamine-2-carboxylic acid,2-(Phenylamino)benzoic acid,N-Phenylanthranilic acid |
Chloride channel
|
|
Fenamic acid (N-Phenylanthranilic acid) is a chloride channel blocker that causes renal papillary necrosis in rats. Fenamic acid serves as a parent structure for several nonsteroidal anti-inflammatory drugs (NSAIDs), inc... |
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T22899 |
L-693,403 maleate
|
|
Others
|
|
L-693,403 maleate has analgesic activity. |
|
T13751 |
L-Threonine derivative-1
|
|
Others
|
|
L-Threonine derivative-1 is acetylsalicylic acid-L-threonine ester with potential analgesic activity. |
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T22850 |
ICI 204,448
|
ICI 204448,ICI204448,ICI-204448 |
Opioid Receptor
|
|
ICI 204,448 is a potent κ-opioid agonist with potential analgesic activity for the study of neurological diseases. |
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T27001 |
CGS8216
|
CGS 8216,CGS-8216 |
Others
|
|
CGS8216 is a benzodiazepine receptor antagonist that shows analgesic activity at high doses.CGS8216 has anxiolytic activity and may be used to study immune system disorders. |
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T68046 |
Ciproquazone
|
|
Others
|
|
Ciproquazone has analgesic activity and is used to treat spondylitis. |
|
T25354L1 |
(Abs)-DuP 747-HCl
|
|
|
|
(Abs)-DuP 747-HCl Has analgesic activity and can be used as a diuretic. |
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T28217 |
NTRC-844
|
NTRC 844,NTRC844 |
Neurotensin Receptor
|
|
NTRC-844 is a selective rat neurotensin receptor type 2 (NTS2) antagonist that shows analgesic activity in animal models of pain. |
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T9748 |
Anti-inflammatory agent 34
|
|
Immunology/Inflammation related
|
|
Anti-inflammatory agent 34 shows moderate acute anti-inflammatory activity and analgesic activity in vivo. |
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T68057 |
Doxpicomine
|
|
Others
|
|
Doxpicomine has analgesic activity and can be used to treat postoperative pain. |
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T14546 |
Bermoprofen
|
AD-1590,AJ-1590 |
Others
|
|
Bermoprofen (AD-1590) is an orally active non-steroidal anti-inflammatory compound with anti-inflammatory and analgesic activity used in the study of gastric ulcers. |
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T27667 |
JNJ-20788560
|
JNJ 20788560 |
Opioid Receptor
|
|
JNJ-20788560 is a delta opioid receptor (DOR) agonist with analgesic activity. It is more selective for DOR than for mu opioid receptors (MOR). |
|
T26631L |
Anidoxime HCl
|
USVP-E142,Anidoxime HCl( 34297-34-2 Free base) |
|
|
Anidoxime HCl (USVP-E142) is a novel orally available compound with anti-analgesic activity. |
|
T26637 |
Antipain dihydrochloride
|
Antipain 2HCl,BDBM-32804,BDBM 32804, Antipain,BDBM32804 |
Protease
|
|
Antipain dihydrochloride (Antipain 2HCl) is a protease inhibitor derived from Actinomycetes that exhibits analgesic activity and inhibits X-ray-induced chromosomal aberrations in human lymphocytes. |
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T78631 |
Ac-YVAD-AOM
|
|
Caspase
|
|
Ac-YVAD-AOM is a selective and potent caspase-1 inhibitor showing antitumor activity and potential analgesic activity. |
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T68152 |
Talmetacin
|
|
Others
|
|
Talmetacin has anti-inflammatory and analgesic and anti-tumour activity and can be used to study cardiovascular disease. |
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T34485 |
Safotibant
|
LF220542,LF 220542,LF 22-0542,LF-220542,LF-22-0542,LF22-0542 |
Bradykinin Receptor
|
|
Safotibant (LF-22-0542) is a bradykinin B1 receptor antagonist with anti-inflammatory and analgesic activity for the topical treatment of diabetic macular edema. |
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T12624 |
(R)-Ketorolac
|
(+)-Ketorolac |
Others
|
|
(R)-Ketorolac ((+)-Ketorolac) is the R-enantiomer of Ketorolac, with potent analgesic activity. |
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T7666 |
Valorphin TFA(144313-54-2(free base))
|
Valorphin TFA(144313-54-2(free bas)) |
Others
|
|
Valorphin TFA(144313-54-2(free base)) is a semisynthetic derivative of dihydrovaltrate with opioid analgesic activity |
|
T77676 |
(Z)-Metanicotine 2HCl
|
(Z)-Metanicotine 2HCl(1129-68-6 Free base) |
Others
|
|
(Z)-Metanicotine 2HCl has analgesic activity and is used in the treatment of central system disorders. |
|
T14076 |
A 839977
|
A839977,A-839977 |
P2X Receptor
,
Calcium Channel
|
|
A 839977 is a selective P2X7 receptor antagonist with anti-inflammatory and analgesic activity that inhibits BzATP-induced calcium efflux from the P2X7 receptor for the study of renal fibrosis. |
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T19641 |
Epirizole
|
DA 398,Mepirizole,DA398,Mebron,Methopyrimazole,Dalex,DA-398 |
Others
|
|
Epirizole (Mebron) shows antipyretic, analgesic, and anti-inflammatory activity and can be used in studies about chronic rheumatoid arthritis. |
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T68068L |
(R)-CJ 11974
|
|
Neurokinin receptor
|
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(R)-CJ 11974 is a novel non-peptide neurokinin NK1 substance P receptor antagonist with potential analgesic activity that can be used to study chemotherapy-induced vomiting. |
|
T15052 |
Dapansutrile
|
|
NOD-like Receptor (NLR)
,
NOD
|
|
Dapansutrile is a potent, selective and orally active NLRP3 inflammasome inhibitor, with Anti-inflammatory and analgesic activity. |
|
T28453L |
Propiram fumarate HCl
|
Propiram fumarate HCl(15686-91-6 Free base) |
Opioid Receptor
|
|
Propiram fumarate HClis an orally available Opioid receptors agonist with analgesic activity for the study of musculoskeletal pain. |
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T28089 |
MPGES-1 Inhibitor-1
|
|
Prostaglandin Receptor
|
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mPGES-1 Inhibitor-1 is a novel selective inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1) with anti-inflammatory and analgesic activity for the study of acute liver injury. |
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T30824 |
Cgp 29030A
|
Cgp29030A,Cgp-29030A |
Others
|
|
CGP 29030A is a new piperazine derivative with analgesic activity and significant inhibitory effect on potentially nociceptive dorsal horn neurons, which can be used to study painful disorders. |
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T72282 |
Ebaresdax hydrochloride
|
|
Endogenous Metabolite
|
|
Ebaresdax hydrochloride has analgesic activity and is used in the study of painful diabetic neuropathy caused by type I or type II diabetes. |
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T39529 |
AT-121 hydrochloride
|
|
Opioid Receptor
|
|
AT-121 hydrochloride is a dual agonist of nociception and mu opioid receptor with Ki values of 3.67 and 16.49 nM, respectively.AT-121 hydrochloride is a safe, non-addictive, pain relieving compound with anti-injury and a... |
|
T0943 |
Carbamazepine
|
NSC 169864 |
Mitophagy
,
Sodium Channel
,
Autophagy
|
|
Carbamazepine (NSC-169864) is a tricyclic compound chemically related to tricyclic antidepressants (TCA) with anticonvulsant and analgesic properties. Carbamazepine exerts its anticonvulsant activity by reducing polysyna... |
|
T0470 |
Nefopam hydrochloride
|
Fenazoxine hydrochloride,Nefopam HCl |
Wnt/beta-catenin
,
Sodium Channel
|
|
Nefopam hydrochloride (Nefopam HCl) is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity. |
|
T26926 |
Butibufen
|
FF 105,FF-106,FF 106,FF106 |
Lipoxygenase
|
|
Butibufen (FF-106) is an orally active non-steroidal anti-inflammatory compound, a potential cyclooxygenase inhibitor with analgesic and antipyretic activity, and inhibits urea synthesis.Butibufen has been used in the st... |
|
T4351 |
DAMGO
|
Dagol,DAGO,RX-783006 |
Opioid Receptor
|
|
DAMGO (DAGO) is an opioid receptor agonist with the ability to affect the locomotive activity in rodents. Possible analgesic agent due to μ-opiod receptor interaction. |
|
T69552 |
Suzetrigine
|
VX-548 |
Sodium Channel
|
|
Suzetrigine（VX-548） is an orally active and specific NaV1.8 inhibitor. Suzetrigine has analgesic activity and can be used to study acute pain and neurotransmission. |
|
T25615 |
Lanepitant
|
LY303870,LY-303870,LY 303870 |
Others
|
|
Lanepitant (LY303870) is a nonpeptide neurokinin-1 (NK-1) antagonist with analgesic activity that inhibits neurogenic dura mater inflammation and is used for the prevention of migraine. |
|
T22576 |
Anpirtoline hydrochloride
|
D-16949 hydrochloride |
5-HT Receptor
|
|
Anpirtoline hydrochloride (D-16949 hydrochloride) is a novel and potent 5-HT1B receptor agonist and 5-HT3 receptor antagonist with anti-injurious, analgesic, and antidepressant activity, and is used in the study of movem... |
|
T68052 |
Delmetacin
|
Demethacin |
CXCR
|
|
Delmetacin (Demethacin) is a non-steroidal anti-inflammatory compound with anti-inflammatory and analgesic activity and inhibitory effects on the CXC chemokine receptor CXCR1. |
|
T68127 |
Picenadol
|
LY-150720,LY150720,LY 150720 |
Others
|
|
Picenadol (LY 150720) is a racemic mixture of N-methyl-4-phenylpiperidine derivatives with agonist-antagonist opioid properties.Picenadol has central analgesic activity. |
|
T22489 |
2'-MeCCPA
|
2-Chloro-N-cyclopentyl-2′-C-methyladenosine |
HCV Protease
,
Adenosine Receptor
|
|
2'-MeCCPA is a potent and highly selective A1 adenosine receptor (A1AR) agonist with a K-value of 1.8 nM for AR.2'-MeCCPA inhibits trichostatin-stimulated adenylate cyclase activity with an IC value of 13.1 nM.2'-MeCCPA ... |
|
T40377 |
Nicotredole
|
Tryptamide |
Others
|
|
Nicotredole (Tryptamide) (Tryptamide) is an orally active analgesic and anti-inflammatory agent. Nicotredole exhibits evident anti-inflammatory effects of potency comparable with Phenylbutazone. Nicotredole has only weak... |
|
T10003 |
α1 adrenoceptor-MO-1
|
|
Others
|
|
α1 adrenoceptor-MO-1 (S enantiomer) has affinity at alpha 1 adrenergic receptor with alphalytic activity and analgesic action. It has more active than R enantiomer. |
|
T27335 |
Floctafenine
|
RU 15750,R-4318,R 4318,RU-15750,R4318 |
COX
|
|
Floctafenine (R-4318) is an orally available nonsteroidal anti-inflammatory compound that is a COX-I and COX-2 inhibitor and interferes with the antiplatelet effects of aspirin.Floctafenine has analgesic activity and is ... |
|
T76341L |
[DPro10] Dynorphin A (1-11)acetate,porcine
|
[DPro10] Dynorphin A (1-11)acetate,porcine(94596-26-6 Free base) |
Opioid Receptor
|
|
[DPro10] Dynorphin A (1-11)acetate,porcine is a highly potent κ-opioid receptor agonist with a Ki value of 0.13 nM. [DPro10] Dynorphin A (1-11), porcine is an n-alkylated derivative with analgesic activity. |
|
T0386 |
Ropivacaine hydrochloride
|
Ropivacaine monohydrochloride |
Potassium Channel
,
Sodium Channel
|
|
Ropivacaine hydrochloride (Ropivacaine monohydrochloride) is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity. |
|
T79499 |
KSK68
|
|
Histamine Receptor
|
|
KSK68 is a potent dual sigma-1 and histamine H3 receptor antagonist with potential analgesic activity and high affinity for H3 receptors, sigma-1, sigma-2 receptors.KSK68 can be used in the study of pain related diseases... |
|
T23333 |
SC-58125
|
SC 58125 |
COX
|
|
SC-58125 is a selective cyclooxygenase 2 (COX-2) inhibitor, with an IC50 of 0.04 μM. SC-58125 exhibits antitumor activity in vitro and in vivo, and it also can inhibit edema at the inflammatory site and is analgesic |
|
T1002 |
Etodolac
|
Ultradol,AY-24236,Etodolic acid,Lodine |
Retinoid Receptor
,
COX
|
|
Etodolac (AY-24236) inhibits the activity of cyclooxygenase I and II, thereby preventing the formation of prostaglandin which is involved in the induction of pain, fever, and inflammation. Etodolac is a pyranocarboxylic ... |
|
T1394 |
Ibuprofen
|
Brufen,(±)-Ibuprofe,Motrin,Advil |
COX
|
|
Ibuprofen (Advil) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resu... |
